Pharmatrope is a computational chemistry company focused on increasing speed and success in moving drugs to the clinic. Our software suite enables drug design teams to explore new, diverse chemical types more efficiently by pre-screening new designs in silico. Drug candidates with the best combinations of high potency and low downstream liabilities are identified and progressed with increased confidence of success. In addition to the software toolkit itself, our computational services team is skilled in the application of the software and is available to augment existing computational resources.

Biographical Sketches

Jeffrey Wiseman, Ph.D.
Principal and Co-Founder
Pharmatrope, Ltd.

Dr. Wiseman has 30 years of experience in discovery research in the pharmaceutical industry. Prior to the founding of Pharmatrope, he led efforts at Locus Pharmaceuticals for five years to develop cutting edge computational drug design software for the accurate and rapid prediction of ligand binding affinities. This followed service as Global Vice President of Cheminformatics at GlaxoSmithKline where his division created the informatics underpinning industrialization of high-throughput screening and chemistry. Prior to building the Cheminformatics division at GSK, Dr. Wiseman held multiple positions at Glaxo Wellcome, including service on the global Research Executive council, leading the therapeutic area teams in Inflammation, and leading departments of Biochemistry, Structural Biology, and Molecular Biology. Dr. Wiseman holds a degree in Chemistry from Harvard University and trained as a Postdoctoral Research Fellow in Enzymology at Stanford and Brandeis Universities.

Matthew Clark, Ph.D.
Principal and Co-Founder
Pharmatrope, Ltd.

Dr. Clark has 20 years experience creating and using software tools for pharmaceutical discovery research. Prior to founding Pharmatrope he led the Locus software and research team at Locus Pharmaceuticals developing free energy simulations on one of the world's largest clustered supercomputers. Before this he worked in the information industry as Director of New Product Development and Marketing at the Institute for Scientific Information, specializing in chemical information products. He also had extensive experience at Tripos Inc. leading software development teams as a product manager and Director of marketing. Both of those positions involved international travel to discuss research needs with information scientists and discovery groups at nearly every major pharmaceutical research site in the world. Dr. Clark studied at Virginia Tech and the University of Alabama.